Muppet Theater is bankrupt. The members of The Muppets are switching professions. And Muppet Theater will be torn down except The Muppets could collect $ 10 million in short time.
Tex Richman (Chris Cooper), an oil merchant plans to knock down Muppet Theater, because under this building there are oil fields. Fortunately, there is Walter (Peter Linz), Gary (Jason Segel), and Mary (Amy Adams) who tried to prevent this theater was demolished.
They are fans of The Muppets and didn’t want if Muppet Theater ruined. The Kermit tried to collect the other members. Now, Fozzie is busy with his new band, while Miss Piggy become the fashion editor of Vogue magazine in Paris, Animal do therapy to relieve his emotions, while Gonzo became the pipe repair business entrepreneurs. Can they reunite to save Muppet Theater?